What the Data Says

What the Data Says

Review the key studies on ACTIFUSE in more detail.

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ACTIFUSE Advantage

ACTIFUSE Advantage

Understand what distinguishes ACTIFUSE from traditional bone graft substitutes.

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Contact a Baxter rep in your area.

Contact a Baxter rep in your area.

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How ACTIFUSE Works

Increased Cell Attachment - The patented silicate substitution process provides a dual effect:

  • Ion release - A diffusion process occurs where ions are released into the surrounding environment.1
  • Negative surface charge - At the same time, the silicate alters the surface charge on the graft2 and the resulting negative charge increases the quantity of cell attachment proteins that are adsorbed by the graft.1

Accelerated Bone Formation - With this high concentration of proteins,1 osteoblasts,3 and mesenchymal stem cells1 attachment occurs at a faster rate and in higher numbers.

Natural Remodeling - The graft's chemically stable scaffold is maintained until the material is replaced with bone through the natural healing process of osteoclast and osteoblast remodeling. ACTIFUSE remains as long as it is needed for the patient’s bone to heal.2

References:

  1. Rashid N, Harding IA, Buckland T, Hing KA. Nano-scale manipulation of silicate-substituted apatite chemistry impacts surface charge, hydrophilicity, protein adsorption and cell attachment. Int J Nano and Biomaterials. 2008;1(3):299-319.
  2. Hing KA, Wilson LF, Buckland T. Comparative performance of three ceramic bone graft substitutes. Spine J. 2007; 7(4):475-490.
  3. Guth, K, Campion C, Buckland T, Hing KA. Effect of silicate-substitution on attachment and early development of human osteoblast-like cells seeded on microporous hydroxyapatite discs. Adv Eng Mater. 2010;12(4):B77-B82.